
柳文慧 ;凌小丽 ;张文静 ;刘海燕(通讯作者)
临沂市人民医院,山东 临沂 276000
摘要:目的 分析肺癌患者腔镜术后持续漏气的影响因素,为避免发生持续性漏气干预方案的设计提供参考。方法 检索中国知网、万方、维普、中国生物医学文献服务系统、PubMed、Web of Science、Embase、The Cochrane Library等数据库中关于肺癌术后持续漏气的相关因素的病例对照研究和队列研究,横断面研究,检索时限为建库至2025年8月。结果 共纳入12篇文献,9017例肺癌腔镜术后患者,确定了20个与肺癌患者腔镜术后持续性漏气相关的影响因素,包括⑴患者自身因素:人口学因素:性别、年龄。既往史:吸烟史。肺质量因素:呼吸合并症、FEV1/FVC、LER、ER、肺裂发育不良。合并基础疾病:心血管疾病。营养状态:BMI、FFMI、血清白蛋白水平、前蛋白水平。⑵病理因素:肿瘤分期、肺癌类型。⑶手术因素:手术类型、手术时间、胸腔黏连松解术、术中估计失血量。⑷医生因素:手术经验。结论 肺癌腔镜术后持续性漏气的发生涵盖多重影响因素,涉及患者自身因素、病理因素、手术因素、医生经验因素等多个维度。医护人员应加强肺癌术后持续漏气高危患者的识别与管理,针对上述多种影响因素提前采取措施,以减少肺癌患者腔镜术后持续漏气的发生,改善患者预后。
关键词:肺癌;胸腔镜手术;持续性漏气;影响因素;范围综述
参考文献:
[1]Chen Y C, Hsu C L, Wang H M, et al. Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers[J]. Cancer Res, 2025,85(3):602-617.
[2]滕艳华, 马宁. 胸腔镜下肺部肿瘤切除术后合并持续性肺漏气患者心理体验的质性研究[J]. 护士进修杂志, 2021,36(21):2012-2015.
[3]Ma S, Li F, Li J, et al. Risk factor analysis and nomogram prediction model construction of postoperative complications of thoracoscopic non-small cell lung cancer[J]. J Thorac Dis, 2024,16(6):3655-3667.
[4]Oh S G, Jung Y, Jheon S, et al. Postoperative air leak grading is useful to predict prolonged air leak after pulmonary lobectomy[J]. J Cardiothorac Surg, 2017,12(1):1.
[5]Zheng Q, Ge L, Zhou J, et al. Risk factors for prolonged air leak after pulmonary surgery: A systematic review and meta-analysis[J]. Asian Journal of Surgery, 2022,45(11):2159-2167.
[6]Saha B K, Chong W H, Hu K, et al. Pressure-dependent persistent air leak in a patient with secondary spontaneous pneumothorax[J]. Am J Med Sci, 2022,364(6):782-788.
[7]Zhao K, Mei J, Xia C, et al. Prolonged air leak after video-assisted thoracic surgery lung cancer resection: risk factors and its effect on postoperative clinical recovery[J]. J Thorac Dis, 2017,9(5):1219-1225.
[8]Arksey H, O'Malley L. Scoping studies: towards a methodological framework[J]. International journal of social research methodology, 2005,8(1):19-32.
[9]谢鹏飞, 陈佳, 张晓东, 等. 肺叶气肿比值预测NSCLC 电视胸腔镜肺叶切除术后持续性漏气的临床分析[J]. 中华肺部疾病杂志(电子版), 2024,17(6):907-912.
[10]张宏恩, 严燕燕. 胸腔镜下肺癌术后患者持续性肺漏气的影响因素分析[J]. 养生科学, 2024(6):19-22.
[11]汤平, 束余声. 腔镜肺癌术后持续性肺漏气相关危险因素分析[J]. 中文科技期刊数据库(全文版)医药卫生, 2023(5):57-59.
[12]Ponholzer F, Ng C, Maier H, et al. Risk factors, complications and costs of prolonged air leak after video-assisted thoracoscopic surgery for primary lung cancer[J]. J Thorac Dis, 2023,15(2):866-877.
[13]Yotsukura M, Okubo Y, Yoshida Y, et al. Predictive factors and economic impact of prolonged air leak after pulmonary resection[J]. Gen Thorac Cardiovasc Surg, 2022,70(1):44-51.
[14]Su L, Ho H, Stock C T, et al. Surgeon Experience Is Associated With Prolonged Air Leak After Robotic-assisted Pulmonary Lobectomy[J]. Ann Thorac Surg, 2022,114(2):434-441.
[15]Li S J, Wang Z Q, Zhang W B, et al. Fat-free mass index is superior to body mass index as a novel risk factor for prolonged air leak complicating video-assisted thoracoscopic surgery lobectomy for non-small-cell lung cancer[J]. J Thorac Dis, 2019,11(5):2006-2023.
[16]Moon D H, Park C H, Kang D Y, et al. Significance of the lobe-specific emphysema index to predict prolonged air leak after anatomical segmentectomy[J]. PLoS One, 2019,14(11):e224519.
[17]Murakami J, Ueda K, Tanaka T, et al. Grading of Emphysema Is Indispensable for Predicting Prolonged Air Leak After Lung Lobectomy[J]. Ann Thorac Surg, 2018,105(4):1031-1037.
[18]Okada S, Shimada J, Kato D, et al. Prolonged air leak following lobectomy can be predicted in lung cancer patients[J]. Surg Today, 2017,47(8):973-979.
[19]Luo Y, Luo J, Su Q, et al. Exploring Central and Bridge Symptoms in Patients with Lung Cancer: A Network Analysis[J]. Semin Oncol Nurs, 2024,40(3):151651.
[20]杨欣. 从烟雾到肺癌:探究吸烟与肺癌的关系[J]. 健康向导, 2025,31(08):21-23.
[21]宋宇豪, 田文鑫, 李东航, 等. 老年肺癌患者围术期心肺并发症的早期识别与干预策略[J]. 中国胸心血管外科临床杂志, 2025:1-8.
[22]刘艳虎, 薛栋, 李亚东. 三维重建技术在肺裂发育不全肺癌患者中的应用[J]. 南通大学学报(医学版), 2021,41(06):563-566.
[23]Mattioni G, Palleschi A, Mendogni P, et al. Approaches and outcomes of Robotic-Assisted Thoracic Surgery (RATS) for lung cancer: a narrative review[J]. J Robot Surg, 2023,17(3):797-809.
[24]Feczko A F, Wang H, Nishimura K, et al. Proficiency of Robotic Lobectomy Based on Prior Surgical Technique in The Society of Thoracic Surgeons General Thoracic Database[J]. Ann Thorac Surg, 2019,108(4):1013-1020.