TREM2 在非酒精性脂肪性肝病中的作用研究 - 香港千禾出版集团有限公司

【摘要】髓系细胞触发受体 2（TREM2）是在髓系细胞表面特异性表达的单次跨膜受体，通过调控免疫应答、脂质代谢和细胞存活等过程参与多种病理生理机制。研究发现 TREM2 在非酒精性脂肪性肝病（NAFLD）的发生发展中发挥重要作用，其表达水平与肝脂肪变性、炎症反应、纤维化进程及肝细胞癌发生密切相关。本文综述讲述了 TREM2 的分子特征以及在 NAFLD 中的多重调控机制，提出靶向 TREM2 可能是 NAFLD 治疗的新策略，可为 NAFLD 的精准诊疗提供理论依据。

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